Chlamydia trachomatis expresses phylogenetically homologous proteins to human papilloma virus type 16: inferences for oral and oropharyngeal squamous cell carcinoma

Oral and oropharyngeal squamous cell carcinoma have been linked to infection by human papilloma virus (HPV) types 16 and 18. They produce proteins E6 and E7 that interfere with p53 and pRb1 proteins and hence support oncogenesis. HPV infection is typically via oro-genital contact and other organisms cohabiting the genitalia may have had sufficient time for a genetic exchange with HPV oncoproteins and hence develop oncogenic potential also within the oral cavity.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 17, 2021 Category: ENT & OMF Authors: GO Oboli, EO Abe, AO Adisa Source Type: research