β‐Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes

Despite distinct etiologies and pathogenesis of type  1, type 2 and other types of diabetes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β-cell failure among different types of diabetes. Understanding these susceptibilities and mechanisms can help in the development of therapeutic strategies rega rdless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future prospects as well. AbstractDiabetes mellitus is etiologically classified into type  1, type 2 and other types of diabetes. Despite distinct etiologies and pathogenesis of these subtypes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β-cell failure among different types of diabetes. Understanding these susceptibilities and mecha nisms can help in the development of therapeutic strategies regardless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future pro spects as well.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Review Source Type: research