Metabolo-epigenetics: The interplay of metabolism and epigenetics during early germ cells development

Biol Reprod. 2021 Jun 16:ioab118. doi: 10.1093/biolre/ioab118. Online ahead of print.ABSTRACTMetabolites control epigenetic mechanisms and, conversly, cell metabolism is regulated at the epigenetic level in response to changes in the cellular environnement. In recent years, this metabolo-epigenetic control of gene expression has been implicated in the regulation of multiple stages of embryonic development. The developmental potency of stem cells and their embryonic counterparts is directly determined by metabolic rewiring. Here, we review the current knowledge on the interplay between epigenetics and metabolism in the specific context of early germ cells development. We further develop the implications of metabolic rewiring in primordial germ cells in light of their epigenetic remodelling during cell fate determination. Finally, we discuss the relevance of concerted metabolic and epigenetic regulation of primordial germ cells in the context of mammalian transgenerational epigenetic inheritance.PMID:34132770 | DOI:10.1093/biolre/ioab118
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Source Type: research