NHS to give artificial pancreas to 1,000 diabetics to test if it prevents life-threatening attacks

Patients with type 1 diabetes will be able to use the devices, which continuously measure a person's glucose levels and deliver insulin directly to the bloodstream, Sir Simon Stevens said.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Contributors : Shen Dong ; Jeffrey A BluestoneSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: A previous Phase I study showed that the infusion of autologous Treg cells expanded ex-vivo into recent onset Type 1 Diabetes (T1D) patients had an excellent safety profile, however, the majority of the infused Tregs could no longer be detected in the peripheral blood three months post-infusion (NCT01210664-Treg-T1D Trial). Interleukin-2 (IL-2) is a well-characterized cytokine that has been shown to enhance human Treg cell survival and expansion at low doses in vivo. Therefore, a ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
CONCLUSION: KAP relating to eye disease and eye care among Saudi patients with DM were less than desired. Rigorous efforts are required to raise awareness of eye complications among diabetic patients.
Source: Middle East African Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Altern Ther Health Med. 2021 Sep 24:AT6958. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease leading to an insulin deficiency that causes hyperglycemia and associated symptoms. It is considered the most common type of diabetes, with the 4Ts (going to the toilet a lot, being really thirsty, feeling more tired than usual, losing weight or looking thinner than usual) being the most prevalent symptoms. Non-specific signs and symptoms are also possible, and delaying or missing the diagnosis can have a devastating effect on a child's health. Children with a definitive diagnosis of diabetes often requi...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Toxicol Pathol. 2021 Sep 23:1926233211036395. doi: 10.1177/01926233211036395. Online ahead of print.ABSTRACTIslet-like clusters derived from human embryonic stem cells (hESC) hold the potential to cure type 1 diabetes mellitus. Differentiation protocols of islet-like clusters lead to the generation of minor fractions of nonendocrine cells, which are mainly from endodermal and mesodermal lineages, and the risk of implanting these is unclear. In the present study, the histogenesis and the tumorigenicity of nonendocrine cells were investigated in vivo. Immunodeficient mice were implanted under the kidney capsule with islet-li...
Source: Toxicologic Pathology - Category: Pathology Authors: Source Type: research
CONCLUSIONS: Sleep duration and quality is a modifiable target for potentially improving glycemic levels and parental distress in early school-aged children with T1D.PMID:34559603 | DOI:10.1080/15402002.2021.1977305
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Source Type: research
CONCLUSION: The SCODI can be used for measuring self-care in people with T1DM, T2DM, or mixed groups using identical scoring procedures. Considering the well-known differences between Type 1 and Type 2 diabetes diseases and patients' characteristics, our results support the generalizability of the self-care theory on which the instrument is based.PMID:34559189 | DOI:10.1093/abm/kaab088
Source: Annals of Behavioral Medicine - Category: Psychiatry & Psychology Authors: Source Type: research
CONCLUSIONS: The Swedish guidelines for DM1 during pregnancy and labor lack both consensus and adherence. A national guideline on DM1 during pregnancy and childbirth with high adherence could improve care for pregnant Swedish women with DM1 and their fetuses.PMID:34556439 | DOI:10.1016/j.pcd.2021.08.003
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Prim Care Diabetes. 2021 Sep 20:S1751-9918(21)00174-1. doi: 10.1016/j.pcd.2021.09.002. Online ahead of print.ABSTRACTAIMS: We aimed to demonstrate the relationship between parental consanguinity and positive family histories of type 1 diabetes mellitus (T1DM) and autoimmune disease and the development of T1DM among children in Saudi Arabia.METHODS: This was a cross-sectional case-control study. In total, 192 patients and 188 healthy controls were enrolled from the Pediatric Diabetes Clinic at King Salman Military Hospital between January 2000 and December 2010. Detailed patients' data recorded while distributing questionna...
Source: Primary Care - Category: Primary Care Authors: Source Type: research
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Nature Reviews Endocrinology, Published online: 24 September 2021; doi:10.1038/s41574-021-00576-0Up to one in four women with type 1 diabetes mellitus (T1DM) also have polycystic ovary syndrome (PCOS). Under subcutaneous insulin administration, systemic hyperinsulinism might trigger PCOS in women predisposed to the condition. However, very little is known about the long-term consequences of androgen excess in women with T1DM, and management guidelines are lacking.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research
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