Selection of Conditioning Intensity for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplasia - New Evidence Emerges

Allogeneic hematopoietic stem cell transplantation (allo-SCT) continues to represent the optimal curative treatment strategy in adults with high risk acute myeloid leukemia (AML) or myelodysplasia (MDS). The combination of dose intensification delivered by the conditioning regimen and a potent graft-versus-leukemia effect substantially reduces the risk of disease relapse compared with intensive chemotherapy alone.1,2 However the therapeutic benefit of allo-SCT remains blunted by the toxicity of transplantation -particularly in recipients of myeloablative conditioning (MAC) regimens.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: The Bottom Line Source Type: research