Contractile Differences Detected by Speckle Tracking Echocardiography in Pediatric Patients with Mitral Valve Prolapse

AbstractMitral valve prolapse (MVP) is the most common valvar dysfunction in children. There is emerging evidence that MVP is not always a benign entity, hence identification of underlying mechanisms is pertinent to clinical management. Our group previously identified a ventricular contraction abnormality named end-systolic basal eversion (ESBE) in adults that contributed to MVP. The aim of this study was to evaluate regional circumferential strain in pediatric patients with MVP and ESBE compared to normal controls. Left ventricular circumferential strain was assessed in 16 pediatric patients referred for clinical echocardiographic examination with MVP and ESBE (MVP group) and compared to age-gender-matched healthy subjects. ESBE has been previously described as late systolic bileaflet mitral valve prolapse, papillary traction, and concomitant late systolic outward movement of the basal inferior myocardium. The mean age of the MVP group was 13.8  ± 4.6 year and 75% were female. All patients with MVP and controls had qualitatively normal systolic cardiac function. The MVP group had significantly lower regional strain values for 11/16 of the segments including all 6 basal segments. Importantly, the basal inferior (− 17.02 ± 8.3 2% vs. − 26.10 ± 3.18, p = 0.001) and basal inferolateral (− 19.53 ± 9.76 vs. − 26.10 ± 3.18, p = 0.03) had the lowest strain values compared to the average of all other segments suggesting weaker contrac...
Source: Pediatric Cardiology - Category: Cardiology Source Type: research