An Autopsy Case of Multicentric Castleman Disease Presenting with Severe Jaundice

Intern Med. 2021 Jun 5. doi: 10.2169/internalmedicine.6835-20. Online ahead of print.ABSTRACTA 70-year-old man with multicentric Castleman disease (MCD) was admitted to our hospital with jaundice and ascites. Elevations in his bilirubin and interleukin-6 levels were noted, and computed tomography revealed hepatic atrophy and portal vein and bile duct disorders. Steroid therapy was started for MCD, but he died of hepatic failure. An autopsy revealed that the MCD activity was mild, but advanced fibrosis and cholestasis were observed in the liver. Mild infiltration of IL-6-positive plasma cells was noted in the highly fibrotic area of the liver. Although rare, liver and biliary tract damage may be also considered organ disorders of MCD.PMID:34092729 | DOI:10.2169/internalmedicine.6835-20

Source: Internal Medicine - June 7, 2021 Category: Internal Medicine Authors: Yuichi Yamazaki Yuka Yoshida Megumi Shimizu Takeshi Kobayashi Hiroki Tojima Ken Sato Satoru Kakizaki Hiroshi Handa Hideaki Yokoo Toshio Uraoka Source Type: research