Dissolution, bioactivity behavior, and cytotoxicity of 19.58Li < sub > 2 < /sub > O ·11.10ZrO < sub > 2 < /sub > ·69.32SiO < sub > 2 < /sub > glass-ceramic

J Biomed Mater Res B Appl Biomater. 2021 Jun 14. doi: 10.1002/jbm.b.34889. Online ahead of print.ABSTRACTGlass and bioactive glass-ceramic can be used in several applications. In bone growth where good bone/biomaterial adhesion was required, bioactive coatings for implants can improve bone formation. The glass and glass-ceramics of the LZS (Li2 O-ZrO2 -SiO2 ) system are very interesting because of their mechanical, electrical, and thermal properties. Very recently, their biological response in contact with human osteoblast has been evaluated. However, despite several initiatives, there are still no studies that systematically assess this system's bioactivity, dissolution, and cytotoxicity in vitro. This work aims to investigate the dissolution, bioactivity behavior, and cytotoxicity of LZS glass-ceramic. LZS glass-ceramics were produced from SiO2 , Li2 CO3, and ZrSiO4 by melting followed by quenching. The obtained glass frits were milled and uniaxially pressed and heat-treated at 800 and 900°C and submitted to physical-chemical, structural and mechanical characterization. Their dissolution behavior was studied in Tris-HCl, while bioactivity was performed in simulated solution body fluid (SBF). The cytotoxicity test was performed using glass-ceramic in direct contact with mesenchymal stem/stromal cells (SC) isolated from human exfoliated deciduous teeth. Structural and microstructural analyzes confirmed bioactivity. The results show that it was possible to produce bioactive g...

Source: Biomed Res - June 14, 2021 Category: Research Authors: Nat ália Morelli Possolli Daiara Floriano da Silva Jaqueline Vieira Natasha Maurmann Patricia Pranke Ketner Bendo Dem étrio Elidio Angioletto Oscar Rubem Klegues Montedo Sabrina Arcaro Source Type: research