F1012-2 Induced ROS-Mediated DNA Damage Response through Activation of MAPK Pathway in Triple-Negative Breast Cancer

In conclusion, the activity of F1012-2-induced DNA damage in TNBC was found in vivo and in vitro, which might trigger the MAPK pathway through ROS accumulation. These results indicate that F1012-2 may be an effective anti-TNBC therapeutic agent.PMID:34124254 | PMC:PMC8189789 | DOI:10.1155/2021/6650045

Source: Biomed Res - June 14, 2021 Category: Research Authors: Lingjie Dai Shasha Tian Jinyao Zhang Mengyuan Lu Jingchao Zhu Huajun Zhao Source Type: research