CircRNAs: Decrypting the novel targets of fibrosis and aging

Ageing Res Rev. 2021 Jun 9:101390. doi: 10.1016/j.arr.2021.101390. Online ahead of print.ABSTRACTFibrosis is a typical aging-related pathological process involving almost all organs. It is usually initiated by organic injury and leads to the gradual decline of organ function or even loss. Circular RNAs (circRNAs) are being hailed as a newly rediscovered class of covalently closed transcripts without a 5' cap or 3' tail which draw increasing attention. In particular, circRNAs have been identified to be involved in the multifaceted processes of fibrosis in various organs, including the heart, liver, lung, and kidney. As more and more circRNAs are functionally characterized, they have become novel therapies for fibrosis. In this review, we systematically summarized current studies regarding the roles of circRNAs in fibrosis and shed light on the basis of circRNAs as a potential treatment for fibrosis.PMID:34118443 | DOI:10.1016/j.arr.2021.101390
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research