Serum NMDA Receptor Antibodies Do Not Predict Treatment Response in a Sample of People With First-Episode Psychosis

Autoimmune encephalitis is a rare but potentially life-changing illness in which antibodies damage healthy brain cells. It can present with a wide range of neurological and psychiatric symptoms, from seizures and autonomic instability to depression and anxiety (1). It can also mimic schizophrenia and other psychotic illnesses (1). Since the 1950s, an array of potentially causative autoantibodies has been identified (1), but the NMDA receptor (NMDAR) antibody is the type most consistently associated with psychosis (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Early Career Investigator Commentary Source Type: research