Trace Amine-Associated Receptor 1 Regulates Central Effects of Monoamine Oxidase Inhibitors: Involvement of Tyramine and Glutamate

Trace amines constitute a group of endogenous molecules found in both invertebrates and vertebrates, bearing strong similarities with the monoamine neurotransmitters. The physiological significance of these molecules remained elusive until the discovery in 2001 of a large subfamily of GPCRs (G protein –coupled receptors) interacting with these compounds, the trace amine-associated receptors (TAARs) (1,2). This major breakthrough spurred renewed interest in trace amines and their role in the brain.

Source: Biological Psychiatry - June 14, 2021 Category: Psychiatry Authors: Sophie Gautron Tags: Commentary Source Type: research