Interaction between Ras and Bcl2L12 in B cells suppresses IL-10 expression

In conclusion, Bcl2L12 interacts with Ras activation to compromise immune tolerance in the tonsils by inhibiting the IL-10 expression in tBCs. Inhibition of Bcl2L12 can restore the IL-10 expression in tBCs.PMID:34116211 | DOI:10.1016/j.clim.2021.108775

Source: Clinical Immunology - June 11, 2021 Category: Allergy & Immunology Authors: Jianxiang Li Gui Yang Xiang-Qian Luo Li-Hua Mo Shu-Yao Qiu Li-Tao Yang Da-Bo Liu Yun-Fang An Ping-Chang Yang Source Type: research