Common diabetes drug shows promise as treatment for COVID-19 lung inflammation

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans. Metformin works by lowering glucose production in the liver, reducing blood sugar levels that, in turn, improve the body's response to insulin.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

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The World Food Programme distributing food in El Salvador. The second of the UN's 17 Sustainable Development Goals is to end hunger, achieve food security and improved nutrition and promote sustainable agriculture. Credit: WFP/David FernandezBy Trish CotterMELBOURNE, Sep 21 2021 (IPS) COVID-19 has exposed serious vulnerabilities in how people around the world access and consume food. One of the more alarming trends is the significant increase in the consumption of foods that may be tasty and convenient, but harm our heath. These ultra-processed products include sugary drinks, snack foods, frozen meals, packaged breads and ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Climate Change Editors' Choice Featured Food and Agriculture Food Security and Nutrition Global Headlines Health IPS UN: Inside the Glasshouse Poverty & SDGs TerraViva United Nations Source Type: news
AbstractCoronavirus disease 2019 (COVID-19) accounts for over 180,000 deaths in the USA. Although COVID-19 affects all racial ethnicities, non-Hispanic Blacks have the highest mortality rates. Evidence continues to emerge, linking the disproportion of contagion and mortality from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a result of adverse social determinants of health. Yet, genetic predisposition may also play a credible role in disease transmission. SARS-CoV-2 enters cells by interaction between SARS-CoV-2 spike protein and the receptor molecule angiotensin converting enzyme 2 (ACE2) expressed on the...
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
ConclusionsMetformin and sulfonylurea could be associated with reduced mortality risk in patients with T2DM who have COVID-19. Furthermore, insulin use could be associated with greater mortality, while DPP-4 inhibitor use could not be. The effects of antidiabetic agents in patients with T2DM who have COVID-19 require further exploration.Systematic Review RegistrationPROSPERO (identifier, CRD42021242898).
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Pediatr Endocrinol Diabetes Metab. 2021;27(2):134-140. doi: 10.5114/pedm.2021.107166.ABSTRACTMetformin is a widely used biguanide drug recommended as a first-line antidiabetic for type 2 diabetes. Currently, metformin is used not only in the treatment of diabetes but also in other diseases. Some studies have shown that metformin causes weight loss in insulin-sensitive and insulin-resistant overweight and obese patients. Metformin is an effective and safe option for women with gestational diabetes and type 2 diabetes in pregnancy, and it may also increase the ovulation rate in patients with polycystic ovary syndrome (PCOS)....
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Source Type: research
Ann Med. 2021 Dec;53(1):1642-1645. doi: 10.1080/07853890.2021.1975042.ABSTRACTOBJECTIVE: To compare patients with DKA, hyperglycaemic hyperosmolar syndrome (HHS), or mixed DKA-HHS and COVID-19 [COVID (+)] to COVID-19-negative (-) [COVID (-)] patients with DKA/HHS from a low-income, racially/ethnically diverse catchment area.METHODS: A cross-sectional study was conducted with patients admitted to an urban academic medical center between 1 March and 30 July 2020. Eligible patients met lab criteria for either DKA or HHS. Mixed DKA-HHS was defined as meeting all criteria for either DKA or HHS with at least 1 criterion for the ...
Source: Annals of Medicine - Category: Internal Medicine Authors: Source Type: research
Blood Cells Mol Dis. 2021 Sep 9;92:102604. doi: 10.1016/j.bcmd.2021.102604. Online ahead of print.ABSTRACTPatients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, thi...
Source: Blood Cells, Molecules and Diseases - Category: Hematology Authors: Source Type: research
Pediatr Endocrinol Diabetes Metab. 2021;27(2):134-140. doi: 10.5114/pedm.2021.107166.ABSTRACTMetformin is a widely used biguanide drug recommended as a first-line antidiabetic for type 2 diabetes. Currently, metformin is used not only in the treatment of diabetes but also in other diseases. Some studies have shown that metformin causes weight loss in insulin-sensitive and insulin-resistant overweight and obese patients. Metformin is an effective and safe option for women with gestational diabetes and type 2 diabetes in pregnancy, and it may also increase the ovulation rate in patients with polycystic ovary syndrome (PCOS)....
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Source Type: research
Blood Cells Mol Dis. 2021 Sep 9;92:102604. doi: 10.1016/j.bcmd.2021.102604. Online ahead of print.ABSTRACTPatients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, thi...
Source: Blood Cells, Molecules and Diseases - Category: Hematology Authors: Source Type: research
Pediatr Endocrinol Diabetes Metab. 2021;27(2):134-140. doi: 10.5114/pedm.2021.107166.ABSTRACTMetformin is a widely used biguanide drug recommended as a first-line antidiabetic for type 2 diabetes. Currently, metformin is used not only in the treatment of diabetes but also in other diseases. Some studies have shown that metformin causes weight loss in insulin-sensitive and insulin-resistant overweight and obese patients. Metformin is an effective and safe option for women with gestational diabetes and type 2 diabetes in pregnancy, and it may also increase the ovulation rate in patients with polycystic ovary syndrome (PCOS)....
Source: Pediatric Endocrinology, Diabetes, and Metabolism - Category: Endocrinology Authors: Source Type: research
Eur J Endocrinol. 2021 Sep 1:EJE-21-0721.R1. doi: 10.1530/EJE-21-0721. Online ahead of print.ABSTRACTIn this SARS-COV2-pandemic, diabetes mellitus soon emerged as one of the most prominent risk factors for a severe course of COVID-19 and increased mortality due to hyperglycemia/insulin resistance, obesity, inflammation, altered immune status and cardiovascular complications. In general, men are at a higher risk of severe or fatal COVID-19 disease irrespective of age, region and despite comparable infection rates in both sexes. In COVID-19, there is also a male predominance among hospitalised patients with diabetes, however...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
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