Immunotherapy in Xeroderma Pigmentosum: a case of advanced cutaneous squamous cell carcinoma treated with cemiplimab and a literature review

Oncotarget. 2021 May 25;12(11):1116-1121. doi: 10.18632/oncotarget.27966. eCollection 2021 May 25.ABSTRACTXeroderma Pigmentosum (XP) is a rare genetic disorder with a poor prognosis due to high photosensitivity in affected patients. Herein, we describe the first case of the use of cemiplimab in a patient with XP, a 19-year-old girl presented with locally advanced squamous cell carcinoma of the right periorbital and nasal region. This treatment has been undertaken after a cycle of proton beam radiotherapy. Besides, it is reported a description of the few cases in the literature describing the effectiveness of immunotherapy on skin cancers in XP-patients. This case is in line with those reported, underlining how anti-PD1 monoclonal antibodies may be a promising treatment in this genodermatosis.PMID:34084285 | PMC:PMC8169062 | DOI:10.18632/oncotarget.27966
Source: Oncotarget - Category: Cancer & Oncology Authors: Source Type: research