Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol

Arch Microbiol. 2021 Jun 10. doi: 10.1007/s00203-021-02377-5. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the antioxidant, antibacterial, and antibiofilm activities of nerolidol. The antioxidant activity of nerolidol was determined using the total antioxidant activity method. Antibacterial activity was performed using the microdilution method to determine the minimum inhibitory concentration (MIC) against seven standard strains of the ATCC and four bacterial clinical isolates with a resistance profile, following the Clinical and Laboratory Standards Institute (CLSI). The antibiofilm activity of nerolidol was performed using the crystal violet method. The results of the antioxidant test revealed a total antioxidant activity of 93.94%. Nerolidol inhibited the growth of Staphylococcus aureus (MIC = 1 mg/mL), Streptococcus mutans (MIC = 4 mg/mL), Pseudomonas aeruginosa (MIC = 0.5 mg/mL), and Klebsiella pneumoniae (MIC = 0.5 mg/mL). For clinical isolates, nerolidol showed an inhibitory potential against multidrug-resistant P. aeruginosa, K. pneumoniae carbapenemase (MIC = 0.5 mg/mL), methicillin-susceptible S. aureus (MIC = 2 mg/mL), and methicillin-resistant S. aureus (MIC = 2 mg/mL). Nerolidol showed similar antibacterial activity against ATCC strains and hospital clinical isolates with resistance profile, suggesting that even though these strains are resistant to antibiotics, they are still sensitive to nerolidol. Nerolidol exerted a dose-dependent effec...

Source: Archives of Microbiology - June 10, 2021 Category: Microbiology Authors: Danielle Feij ó de Moura Tamiris Alves Rocha Dayane de Melo Barros Marllyn Marques da Silva Marcielle Dos Santos Santana Beatriz Mendes Neta Isabella Mac ário Ferro Cavalcanti Ren é Duarte Martins M árcia Vanusa da Silva Source Type: research