Preliminary Study of microRNAs Allele-Specific Targeting in Allergic Rhinitis Patients from Central China

CONCLUSION: miR-1244, miR-4651 and miR-7641 may play important roles in the process of AR. Sequencing analysis indicated that three kinds of mutations exist in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. Single miRNA or, more probably, their sets hold the promise for their use as biomarkers of allergic rhinitis. They may also be promising targets in future therapies.PMID:34082667 | DOI:10.2174/1386207324666210603112727
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Source Type: research