Vitamin C deficiency inhibits non-alcoholic fatty liver disease progression through impaired de novo lipogenesis

Despite the increasing clinical importance of nonalcoholic fatty liver disease (NAFLD), little is known about its underlying pathogenesis or specific treatment. The senescence marker protein 30 (SMP30), which regulates the biosynthesis of vitamin C in many mammals except primates and humans, was recently recognized as a gluconolactonase. However, the precise relation between vitamin C and lipid metabolism in NAFLD is not completely understood. Therefore, we aimed to clearly reveal the role of vitamin C in NAFLD progression.

Source: American Journal of Pathology - June 11, 2021 Category: Pathology Authors: Seoung-Woo Lee, Su-Min Baek, Kyung-Ku Kang, A-Rang Lee, Tae-Un Kim, Seong-Kyoon Choi, Yoon-Seok Roh, Il-Hwa Hong, Sang-Joon Park, Tae-Hwan Kim, Kyu-Shik Jeong, Jin-Kyu Park Tags: Regular Article Source Type: research