Fragment-based drug discovery for RNA targets
ChemMedChem. 2021 Jun 8. doi: 10.1002/cmdc.202100324. Online ahead of print.ABSTRACTRapid development within the fields of both fragment-based drug discovery (FBDD) and medicinal targeting of RNA provides possibilities for combining technologies and methods in novel ways. This review provides an overview of fragment-based screening (FBS) against RNA targets, including a discussion of the most recently used screening and hit validation methods such as NMR, X-ray crystallography, and virtual screening methods. A discussion of fragment library design based on research from small molecule RNA binders provides an overview on both the currently limited guidelines within RNA-targeting fragment library design, and future possibilities. Finally, future perspectives are provided on screening and hit validation methods not yet used in combination with both fragment screening and RNA-targets.PMID:34101375 | DOI:10.1002/cmdc.202100324
Source: ChemMedChem - Category: Chemistry Authors: Kasper Plenov Lundquist Vipul Panchal Charlotte Held Gotfredsen Ruth Brenk Mads Hartvig Clausen Source Type: research
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