Four-and-a-half LIM domain protein 2 (FHL2) deficiency protects mice from diet-induced obesity and high FHL2 expression marks human obesity

Four-and-a-Half-LIM-domain-protein 2 (FHL2) modulates multiple signal transduction pathways but has not been implicated in obesity or energy metabolism. In humans, methylation and expression of the FHL2 gene increases with age, and high FHL2 expression is associated with increased body weight in humans and mice. This led us to hypothesize that FHL2 is a determinant of diet-induced obesity.

Source: Metabolism - Clinical and Experimental - June 10, 2021 Category: Biomedical Science Authors: Maria P. Clemente-Olivo, Jayron J. Habibe, Mariska Vos, Roelof Ottenhoff, Aldo Jongejan, Hilde Herrema, Noam Zelcer, Sander Kooijman, Patrick C.N. Rensen, Dani ël H. van Raalte, Max Nieuwdorp, Etto C. Eringa, Carlie J. de Vries Source Type: research