First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies

Total marrow irradiation  (TMI) has significantly advanced radiation conditioning for hematopoietic cell transplantation in hematological malignancies by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. However, the relapse rate remains high, and the lack of a prec linical TMI model has hindered scientific advancements. To accelerate TMI translation to the clinic, we developed a TMI delivery system in pre-clinical models.

Source: International Journal of Radiation Oncology * Biology * Physics - June 10, 2021 Category: Radiology Authors: Darren Zuro, Srideshikan Sargur Madabushi, Jamison Brooks, Bihong T. Chen, Janagama Goud, Amandeep Salhotra, Joo Y. Song, Liliana Echavarria Parra, Antonio Pierini, James F Sanchez, Anthony Stein, Monzr Al Malki, Marcin Kortylewski, Jeffrey Y.C. Wong, Par Source Type: research