Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score
CONCLUSION: PRS facilitates personalization of BC risk among carriers of PVs in predisposition genes. Incorporating PRS into BC risk estimation may help identify > 30% of CHEK2 and nearly half of ATM carriers below the 20% lifetime risk threshold, suggesting the addition of PRS may prevent overscreening and enable more personalized risk management approaches.PMID:34101481 | DOI:10.1200/JCO.20.01992
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Chi Gao Eric C Polley Steven N Hart Hongyan Huang Chunling Hu Rohan Gnanaolivu Jenna Lilyquist Nicholas J Boddicker Jie Na Christine B Ambrosone Paul L Auer Leslie Bernstein Elizabeth S Burnside A Heather Eliassen Mia M Gaudet Christopher Haiman David J H Source Type: research