Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation

In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530

Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research