Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray [Neuroscience]

Galanin receptor1 (GalR1) transcript levels are elevated in the rat ventral periaqueductal gray (vPAG) after chronic mild stress (CMS) and are related to depression-like behavior. To explore the mechanisms underlying the elevated GalR1 expression, we carried out molecular biological experiments in vitro and in animal behavioral experiments in vivo. It...

Source: Proceedings of the National Academy of Sciences - June 9, 2021 Category: Science Authors: Yutao Yang, Yueting Li, Bo Liu, Chenchen Li, Ziȷin Liu, Jiahui Deng, Hanȷiang Luo, Xiaoxiao Li, Jinȷin Wu, Hui Li, Chuan–Yue Wang, Ming Zhao, Haohao Wu, Francois Lallemend, Per Svenningsson, Tomas G. M. Hokfelt, Zhi–Qing D Tags: Neuroscience Biological Sciences Source Type: research