Effects of the TNFRSF11B Mutation Associated With Calcium Pyrophosphate Deposition Disease in Osteoclastogenesis in a Murine Model
ConclusionThese findings indicate that OPG-XL is a loss-of-function mutation as it relates to RANKL-mediated osteoclastogenesis, and thus may permit increased osteoclast numbers and heightened bone turnover. Further studies are necessary to demonstrate how this mutation contributes to arthritis in individuals carrying this mutation.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Elizabeth Mitton āFitzgerald,
Claudia M. Gohr,
Charlene J. Williams,
Amaryllis Ortiz,
Gabriel Mbalaviele,
Ann K. Rosenthal Tags: Brief Report Source Type: research