Response to: ‘Effectiveness of allopurinol on reducing mortality: Time‐related biases in observational studies’

AbstractWe read with great interest the manuscript by Suissa et al that reviewed observational studies of the association between allopurinol and mortality in individuals with gout (1). Suissa describes immeasurable time bias as time periods during which prescription medication records are not available (e.g. hospitalizations), leading to at-risk time being potentially misclassified as unexposed-time. Suissa recommends accounting for the possibility of immeasurable time bias by evaluating hospitalizations during follow-up or using an analytic approach that is weighted by measurable time (2).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research