Dietary citrulline does not modify rat colon tumor response to chemotherapy, but failed to improve nutritional status

During cancer therapy many patients experience significant malnutrition, leading to decreased tolerance to chemotherapy and decreased survival. Dietary citrulline supplementation improves nutritional status in situations such as short bowel syndrome and aging, and is of potential interest in oncology. However, a mandatory prerequisite is to test this amino acid for interaction with tumor growth and chemotherapy response.Dietary citrulline (Cit; 2 %), or an isonitrogenous mix of non-essential amino acids (control), was given to Ward colon tumor-bearing rats the day before chemotherapy initiation.

Source: Clinical Nutrition - June 9, 2021 Category: Nutrition Authors: C. Breuillard, C. Moinard, A. Goron, N. Neveux, A. De Reviers, V. Mazurak, L. Cynober, V.E. Baracos Tags: Original article Source Type: research