3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia

ConclusionsThese findings support single voxel placement targeting nociceptive processing areas in prior1H-MRS studies, but also highlight other areas not as commonly targeted, such as PCC, as important for chronic pain pathophysiology. Identifying target brain regions linked to multidimensional symptoms of fibromyalgia (e.g., negative cognitive/affective response to pain, clinical pain, evoked pain sensitivity) may aid the development of neuromodulatory and individualized therapies. Furthermore, efficient multi-region sampling with 3D MRSI could reduce the burden of lengthy scan time for clinical research applications of molecular brain-based mechanisms supporting multidimensional aspects of fibromyalgia.

Source: European Journal of Pain - June 9, 2021 Category: Anesthesiology Authors: Jeungchan Lee, Ovidiu C. Andronesi, Angel Torrado ‐Carvajal, Eva‐Maria Ratai, Marco L. Loggia, Akila Weerasekera, Michael P. Berry, Dan‐Mikael Ellingsen, Laura Isaro, Asimina Lazaridou, Myrella Paschali, Arvina Grahl, Ajay D. Wasan, Rob Tags: ORIGINAL ARTICLE Source Type: research