Whole-exome sequencing in osteosarcoma with distinct prognosis reveals disparate genetic heterogeneity

Osteosarcoma (OS) is the most common primary malignant bone cancer, with incidence of 2 ∼3 cases per million in children and adolescents, bone cancer is one of the five most common malignant tumor causes of death among adolescents [1]. Many subtypes of OS have been described in the 2013 World Health Organization classification, the most common of which is conventional OS [2]. However , the biological behaviors of OS tumors are quite different, even within the same subtype. Following chemotherapeutic and surgical treatment, some patients don't experience recurrence or metastasis, and ultimately achieve complete disease clearance, while others exhibit drug resistance and disease p rogression, recurrence, metastasis and even death.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research