Restoring VTA DA neurons excitability accelerates emergence from sevoflurane general anesthesia of anxiety state

In this study, we report an anxious state results in delayed awakening in anxiety model mice from sevoflurane general anesthesia. More profound inhibition of DA neurons in the VTA contributes to delayed awakening. Optogenetic stimulation of VTA DA neurons can reverse the delay. The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety.PMID:34090206 | DOI:10.1016/j.bbrc.2021.05.079

Source: Biochemical and Biophysical Research communications - June 5, 2021 Category: Biochemistry Authors: Hui Wang Le Yu Yuan-Jun Qin Ming Chen Xin Wang Huo-Qing Luo Pei-Lin Cong Xiao-Li Wang Hong-Miao Cai Ai-Lian Zhang None Juan-Guo Xiao-Hui Sun Zhao Li Ming Xue Na Sun Qing-Xiu Wang Ji Hu Source Type: research