Cortical adult neurogenesis and its biological implication

AbstractIt is well established that adult neurogenesis occurs in the subventricular zone and the subgranular zone, but a controversy remains about adult neurogenesis in other regions. The cerebral cortex is the most controversial site and has long been of interest to not only neuroscientists but also scientists with broad backgrounds and medical doctors since the late nineteenth century. However, recent studies are gradually clarifying that neurogenesis in the adult cerebral cortex occurs, especially under pathological conditions. These studies suggest that endogenous neural stem cells and/or progenitor cells may exist in or around the cerebral cortex and be useful for regenerative cell therapy in cases of brain insults and diseases. In this review, I summarize recent literatures concerning neurogenesis in the adult cerebral cortex and discuss the possibility of cell therapy for cortex-related disorders.
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research