Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus

Conclusions/interpretationDeletion of ER α in T cells caused impaired maternal adaptation of insulin secretion, changes in hepatokine profiles, and enhanced chronic inflammation in gWAT alongside an abnormal increase in Th17 cells. These results suggest that the ERα-mediated oestrogen signalling effects in T cells regulate T cell immunit y and contribute to glucose homeostasis in pregnancy.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research