Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats

Biomed Res. 2021;42(3):115-119. doi: 10.2220/biomedres.42.115.ABSTRACTThe basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.PMID:34092753 | DOI:10.2220/biomedres.42.115

Source: Biomed Res - June 7, 2021 Category: Research Authors: Yuji Kanazawa Mamoru Nagano Satoshi Koinuma Shinichi Sugiyo Yasufumi Shigeyoshi Source Type: research