Recombinant antithrombin attenuates acute respiratory distress syndrome in experimental endotoxemia

Sepsis-induced endothelial acute respiratory distress syndrome (ARDS) is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocalyx from septic vasculitis; however, the underlying mechanism remains unknown. Here, we investigated the effect of rAT administration on vascular endothelial injury under endotoxemia. Lipopolysaccharide (LPS; 20 mg/kg) was intraperitoneally injected into 10-week-old male C57BL/6 mice, and saline or rAT was intraperitoneally administrated at 3 and 24 h after LPS administration.

Source: American Journal of Pathology - June 7, 2021 Category: Pathology Authors: Haruka Okamoto, Isamu Muraki, Hideshi Okada, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Yugo Wakayama, Ayumi Kuroda, Hirotsugu Fukuda, Yuki Kawasaki, Ayane Nishio, Maho Matsuo, Yuto Tamaoki, Risa Inagawa, Shigeo Takashima, Toshiaki Taniguchi, Akio Suz Tags: Regular Article Source Type: research