Primary OA early joint degeneration induced by ER-stress is mitigated by resveratrol

Given the increasing number of people living with OA, due to population aging and rising rates of obesity, there is an urgent need to identify effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with ER stress. The I-ERS mouse, an ER stress driven model of primary OA, was developed to study the role of ER stress in primary OA susceptibility. The I-ERS mouse has the unique ability to induce ER stress in healthy adult I-ERS mouse articular chondrocytes and cartilage, driving joint degeneration that mimics early primary OA.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research