To dose-adjust or not to dose-adjust: lamivudine dose in kidney impairment

Conclusion: As 3TC is a well tolerated drug with a wide therapeutic window, dose adjustment may be unnecessary among PWH with eGFR between at least 30 and 49 ml/min per 1.73 m2 or less. Clinical judgement is key when weighing the risks and benefits of 3TC dose adjustment for PWH experiencing gastrointestinal symptoms or moderate lab abnormalities.
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research