Early-life microbial restitution reduces colitis risk promoted by antibiotic-induced gut dysbiosis in IL-10-/- mice
Perturbations in the early life gut microbiome are associated with increased risk for complex immune disorders like inflammatory bowel diseases. We previously showed maternal antibiotic-induced gut dysbiosis vertically transmitted to offspring increases experimental colitis risk in IL-10 gene deficient (IL-10-/-) mice, a finding that may result from the loss/lack of essential microbes needed for appropriate immunological education early in life. Here, we aimed to identify key microbes required for proper development of the early life gut microbiome that decrease colitis risk in genetically susceptible animals.
Source: Gastroenterology - Category: Gastroenterology Authors: Jun Miyoshi, Sawako Miyoshi, Tom O. Delmont, Candace Cham, Sonny T.M. Lee, Aki Sakatani, Karen Yang, Yue Shan, Megan Kennedy, Evan Kiefl, Mahmoud Yousef, Sean Crosson, Mitchell Sogin, Dionysios A. Antonopoulos, A. Murat Eren, Vanessa Leone, Eugene B. Chan Source Type: research