Downregulation of a Profibrotic TGF β1/CCN2/MMP9 Axis by Triamcinolone Improves Idiopathic Subglottic Stenosis

Idiopathic subglottic stenosis (iSGS) is a progressive fibrotic disease characterized by life-threatening airway narrowing. While the molecular underpinnings are unknown, our previous reports showing that subglottic Serial Intra-Lesional Steroid Injections (SILSI) improves clinical outcomes suggests a steroid-sensitive pathway in iSGS. We conducted a prospective study to determine the changes in profibrotic markers during SILSI to identify steroid-sensitive profibrotic drivers. Seven newly diagnosed iSGS patients were recruited for SILSI.

Source: American Journal of Pathology - June 7, 2021 Category: Pathology Authors: J. Humberto Trevi ño-Villarreal, Justin S. Reynolds, P. Kent Langston, Andrew Thompson, James R. Mitchell, Ramon A. Franco Source Type: research