Infection related mortality in adults and children undergoing allogeneic hematopoietic cell transplantation: An Australian registry report

Allogeneic hematopoietic cell transplantation (HCT) is standard therapy for many hematological malignancies and severe congenital or acquired disorders of the hematopoietic system.1 Whilst improvements in supportive care, patient and donor selection and HCT techniques have increased survival over time, HCT recipients have a high risk of death, with approximately 20-40% 1 year mortality in most patient populations.2-4 The major cause of death is relapse, which accounts for approximately 40% of all deaths, followed by infections at 25% and graft-versus-host disease (GVHD) at 20%.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research