Developmental and behavioral phenotypes in a mouse model of DDX3X syndrome

Mutations in the X-linked gene DDX3X account for ∼2% of intellectual disability in females, often co-morbid with behavioral problems, motor deficits, and brain malformations. DDX3X encodes an RNA helicase with emerging functions in corticogenesis and synaptogenesis.

Source: Biological Psychiatry - June 6, 2021 Category: Psychiatry Authors: Andrea Boitnott, Marta Garcia-Forn, D évina C. Ung, Kristi Niblo, Danielle Mendonca, Yeaji Park, Michael Flores, Sylvia Maxwell, Jacob Ellegood, Lily R. Qiu, Dorothy E. Grice, Jason P. Lerch, Mladen-Roko Rasin, Joseph D. Buxbaum, Elodie Drapeau, Silvia D Tags: Archival Report Source Type: research