Increased FNDC5/IRISIN protein expression in breast cancer tissue is associated with obesity in postmenopausal women

CONCLUSIONS: Our results confirm that women with breast cancer and obesity exhibit an increased irisin expression in their tumorous tissue compared with women with breast cancer and normal BMI. Likewise, in vitro breast cancer cell lines have the capacity to synthesise and express FNDC5/irisin, without any extracellular stimuli, however the microenvironment surrounding these cells in vivo participates in its regulation.PMID:34083413 | DOI:10.1136/jclinpath-2020-207249

Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Mar ía Elena Tejeda Patricia Canto Alberto Tenorio-Torres Letica Orozco-Arguelles Ram ón Mauricio Coral-Vázquez Alejandro Zentella-Dehesa Marcela Leal-Garc ía Claudia Cecilia Vega-Garc ía Ver ónica Bautista-Piña Juan Pablo M éndez Source Type: research