Long-term pretreatment with alendronate inhibits calvarial defect healing in an osteoporotic rat model

ConclusionThe present study shows that long-term pretreatment with alendronate inhibited calvarial defect healing in osteoporotic rats, and this effect could not be reversed by stopping alendronate, switching to parathyroid hormone, or combining with once-weekly parathyroid hormone.
Source: Journal of Bone and Mineral Metabolism - Category: Orthopaedics Source Type: research