Forecasting Individual Patient Response to Radiotherapy in Head and Neck Cancer with a Dynamic Carrying Capacity Model

Purpose: In order for radiotherapy to enter the realm of personalized medicine it will be necessary to model and predict individual patient responses to radiotherapy.Methods and Materials: Here we model tumor dynamics as logistic growth and the effect of radiation as a reduction in the tumor carrying capacity, motivated by the impact of radiation on the tumor microenvironment. The model was assessed on weekly tumor volume data collected for two independent cohorts of head and neck cancer patients from XXXX1 and XXXX2 that received 66-70 Gy in standard daily fractions or with accelerated fractionation.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research