The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction

In this study, we showed that deletion of IP3R2 blocked the antidepressant-like effect induced by calorie restriction.Invivo microdialysis experiments demonstrated that calorie restriction induced an increase in ATP level in the medial prefrontal cortex (mPFC) in na ïve mice but this effect disappeared in IP3R2-knockout mice, suggesting a role of astrocytic ATP in the calorie restriction-induced antidepressant effect. Further experiments showed that systemic administration and local infusion of ATP into the mPFC induced an antidepressant effect, whereas decrea sing ATP by Apyrase in the mPFC blocked calorie restriction-induced antidepressant regulation. Together, these findings support a role for astrocytic ATP in the antidepressant–like effect caused by calorie restriction.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research