Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice

CONCLUSIONS: These data show anti-alcohol effects of Sig-1R antagonism in heavy drinking mice as well as its efficacy in reducing alcohol-induced hyperalgesia, thereby laying the foundation for the development of novel treatments for AUD and associated pain states.PMID:34060104 | DOI:10.1111/acer.14635
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research