A cross-comparison of cognitive ability across 8 genomic disorders

This study aims to understand whether existing data can be leveraged for a cross-comparison of cognitive ability among multiple CNV. We found there is a lack of harmonization among assessment instruments and little standardization for reporting summary data across studies. Despite these limitations, we identified a differential impact of CNV loci on cognitive ability. Our data suggest that future cross-comparisons of CNV disorders will reveal meaningful differences across the phenotypic spectrum, especially if standardized phenotypic assessment is achieved.PMID:34082144 | DOI:10.1016/j.gde.2021.04.001
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research