Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans

A diminution in skeletal muscle mitochondrial function due to ectopic lipid accumulation and excess nutrient intake is thought to contribute to insulin resistance and the development of type 2 diabetes. However, the functional integrity of mitochondria in insulin-resistant skeletal muscle remains highly controversial.

Source: Metabolism - Clinical and Experimental - June 3, 2021 Category: Biomedical Science Authors: Christopher L. Axelrod, Ciaran E. Fealy, Melissa L. Erickson, Gangarao Davuluri, Hisashi Fujioka, Wagner S. Dantas, Emily Huang, Kathryn Pergola, Jacob T. Mey, William T. King, Anny Mulya, Daniel Hsia, Bartolome Burguera, Bernard Tandler, Charles L. Hoppe Source Type: research