Sex-Specific Plaque Signature: Uniqueness of Atherosclerosis in Women

AbstractPurpose of ReviewCardiovascular disease is a leading cause of morbidity and mortality in both men and women, although there are notable differences in presentation between men and women. Atherosclerosis remains the predominant driver of coronary heart disease in both sexes; however, sex differences in atherosclerosis should be investigated further to understand clinical manifestations between men and women.Recent FindingsThere are sex differences in the prevalence, progression, and prognostic impact of atherosclerosis. Furthermore, developing evidence demonstrates unique differences in atherosclerotic plaque characteristics between men and women on both noninvasive and invasive imaging modalities. Coronary microvascular dysfunction may be present even if no obstructive lesions are found. Most importantly, non-obstructive coronary artery disease is associated with a heightened risk of future adverse cardiovascular events and should not be ignored.SummaryThe distinct plaque signature in women should be recognized, and optimal preventive strategies should be performed for both sexes.
Source: Current Cardiology Reports - Category: Cardiology Source Type: research