AI outperforms humans in creating cancer treatments, but do doctors trust it?

(University Health Network) The impact of deploying Artificial Intelligence (AI) for radiation cancer therapy in a real-world clinical setting has been tested by Princess Margaret researchers in a unique study involving physicians and their patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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ConclusionFollow-up cachexia had an early onset, but was not a prognostic factor for overall survival in patients with PDAC. Some adverse events tended to be more frequent in patients with follow-up cachexia than in those without follow-up cachexia.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSION: Our results indicated that DTX-loaded multifunctional heparin-based micelles with desirable antitumor activity and low toxicity possess great potential as a targeted drug delivery system in the treatment of cancer. PMID: 33023456 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
Publication date: December 2020Source: Clinica Chimica Acta, Volume 511Author(s): Yun Huang, Mingxiu Yang, Weiguo Huang
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Contributor : Germain RousseletSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInterferon beta is a central cytokine in the antiviral response and the immunogenicity of cancer therapies. In monocytes, its expression is modulated by a 60 kb downstream eQTL. We found that this eQTL disrupts binding of the C/EBP- β transcription factor to an enhancer interacting with the IFNB1 promoter. This enhancer, that we have called FIRE for Far IFNB1 Regulatory Enhancer, is conserved in murine myeloid cells, where its looping to Ifnb1 is increased in a genetic model of Ifnb1 deregulation. Prec...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Tumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with plastic properties. This review will focus on the evolution of phenotypes and functions of either MSCs or TAMs, which is “educated” by the TME, as well as interactions between MSCs and TAMs contributing to the distinct stages of tumor biology in gastric cancer. MSCs exert immunoregulatory effects on macrophages and ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Cell Death &Disease, Published online: 09 October 2020; doi:10.1038/s41419-020-03062-zMitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
Patients with cancer have been shown to have a higher risk of clinical severity and mortality compared to non-cancer patients with COVID-19. Patients with hematologic malignancies typically are known to have h...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Research Source Type: research
Abstract Type 4 dipeptidyl peptidase (DPP-4) and fibroblast activation protein alpha (FAP-α) are implicated in the pathophysiology of several metabolic disorders. Drugs targeting DPP-4 inhibition are beneficial for glycemic control, whereas FAP inhibition is a potential target for cancer therapies. In contrast to other gliptins, linagliptin displays unique FAP inhibition. We compared biophysical and structural mechanisms of linagliptin binding to DPP-4 and FAP. Linagliptin exhibited high binding affinity (K D ) and a slow off-rate (k off ) when dissociating from DPP-4 (K D 6.6 pM; k off 5.1 ´...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
Abstract Tea is the most popularly consumed beverage in the world. Theaflavin and thearubigins are the key bioactive compounds of black tea that have anticarcinogenic properties as reported in several studies. However, the epigenetic potential of these compounds has not yet been explored. DNA methyltransferase (DNMT) enzymes induce methylation of DNA at cytosine residues and play a significant role in epigenetic regulation and cancer therapy. The present study has explored the role of black tea as a DNMT inhibitor in the prevention of cancer. Herein, the effect of theaflavin has been studied in colon cancer cell l...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
AbstractClinical successes have been achieved with checkpoint blockade therapy, which facilitates the function of T cells recognizing tumor-specific mutations known as neoepitopes. It is a reasonable hypothesis that therapeutic cancer vaccines targeting neoepitopes uniquely expressed by a patient ’s tumor would prove to be an effective therapeutic strategy. With the advent of high-throughput next generation sequencing, it is now possible to rapidly identify these tumor-specific mutations and produce therapeutic vaccines targeting these patient-specific neoepitopes. However, initial reports suggest that when used as a...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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