Relationship between amyloid and tau levels and its impact on tau spreading

ConclusionOutside the entorhinal cortex, abnormal levels of cortical tau on PET are rarely found with A β below 40 CL. Above 40 CL prevalence of T+ accelerates in all areas. Moderate Aβ levels are required before abnormal neocortical tau becomes detectable.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research